Work

Caloric restriction decreases autoimmune disease activity and lowers blood pressure in an experimental model of systemic lupus erythematosus

Year: 2026

Type: article

Abstract: Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that primarily affects women and is associated with high rates of hypertension and obesity. This study tested the hypothesis that caloric restriction would decrease disease activity and lower blood pressure in the NZBWF1 mouse, an obese and hypertensive model of SLE. Caloric restriction mice had decreased SLE disease activity, with lower anti-dsDNA IgG autoantibodies, albuminuria, renal B and T cell infiltration, and blood pressure.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00122.2026

Authors: Jordan A. Rhymes, Luciano D. Mendoza, Jayla D. Sandifer, Jennifer C. Sullivan, Michael J. Ryan, Erin B. Taylor

Institutions: University of Mississippi Medical Center, Augusta University, University of South Carolina, Columbia VA Health Care System

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: American Physiological Society, National Institutes of Health