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Clozapine for Post-traumatic Stress Disorder: Redefining Treatment Resistance in Soldiers without Psychosis

Year: 2026

Type: article

Abstract: Post-traumatic stress disorder (PTSD) often follows a chronic trajectory, with many patients failing to respond to first-line psychotherapy and SSRIs/SNRIs. This case series explores clozapine for treatment-resistant PTSD (TR-PTSD) without psychosis. Seven soldiers showed improved function and reduced aggression at doses of 125-300 mg, suggesting that clozapine warrants further investigation.

Source: Indian Journal of Psychological Medicine

DOI: 10.1177/02537176261469995

Authors: Roshan Monaragala, Miyuru Chandradasa, K.A.L.A. Kuruppuarachchi

Institutions: University of Kelaniya, General Sir John Kotelawala Defence University

Language: English

Topic: Posttraumatic Stress Disorder Research

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7171284218

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Cites: 12

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