Work

Spatial Proteomic Profiling of the Perineural Invasion Niche in Pancreatic Ductal Adenocarcinoma

Year: 2026

Type: preprint

Abstract: This OSF project archives and registers the protocol for a single-center retrospective observational cohort study of the perineural invasion niche in pancreatic ductal adenocarcinoma using archived formalin-fixed, paraffin-embedded tissue specimens. The study compares PNI-positive and PNI-negative cases using PhenoCycler-Fusion spatial single-cell proteomic profiling and filter-aided expansion proteomics (FAXP) of PNI-adjacent and matched control tissue regions, together with standardized pathological assessment, clinicopathological analyses, and survival analyses. This record is a retrospective protocol registration and research timestamp rather than a prospective clinical trial registration. No patient-level data, identifiable clinical information, or identifiable pathological images will be uploaded.

DOI: 10.17605/osf.io/83juh

Author: ZHANG HONGCHEN

Language: English

Topic: Pancreatic and Hepatic Oncology Research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Funders: Westlake University, Westlake Institute for Advanced Study

Award: G295261992

OpenAlex ID: W7171306326

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