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Infrared Irradiation‐Assisted Pd/Cu Catalysis for Sustainable C–N Cross‐Coupling Reactions

Year: 2026

Type: article

Abstract: Herein, a practical and efficient Pd/Cu‐catalyzed Buchwald–Hartwig amination under infrared irradiation is reported. The reaction proceeds under quasi‐solvent‐free, nonanhydrous conditions and without the need for an inert atmosphere, using only a stoichiometric amount of the green solvent cyclopentyl methyl ether (CPME) as the reaction medium. The cooperative Pd/Cu catalytic system, combined with near‐infrared irradiation centered at 1.2 μm, enables high‐yield C–N couplings of aryl iodides and bromides with a variety of secondary amines with a reduced palladium loading (1.5 mol%) and in short reaction times (1–3 h). Overall, this protocol provides a rapid, sustainable, and broadly applicable route to aryl amines, affording good to excellent yields (68%–99%) under operationally simple conditions.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.70714

Authors: Ambra M. Fiore, Angela Punzi, Matteo R. Martina, Pietro Cotugno, Gianluca M. Farinola

Institution: University of Bari Aldo Moro

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,330

OpenAlex ID: W7171330900

FWCI:

Cites: 44

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