Figure 3 from Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib
Year: 2026
Type: other
Abstract: Correlations between the expression of SLFN11 and plasma cell markers and SLFN11 transcriptional regulation in multiple myeloma (MM). A, Scatter plots demonstrating positive correlations between SLFN11 expression and plasma cell markers (n = 844 MM samples from the MMRF CoMMpass study. B, Heatmap displaying the mRNA expression of the top 12 transcription factors and epigenetic enzymes with the strongest correlation with SLFN11 expression (samples are from the MMRF CoMMpass study). Red, high expression; blue, low expression. C, Scatter plot highlighting the positive correlation between SLFN11 and ZBTB38 expression. D, Representative Western blots showing time-dependent effects of super-enhancer inhibitors on SLFN11, ZBTB38, and IRF2 protein levels in MM cell lines. Left, KMS-34 cells treated with JQ1 (BET inhibitor, 500 nmol/L) or THZ1 (CDK7 inhibitor, 200 nmol/L) for 0, 12, 24, and 48 hours. Right, KMS-27 cells treated with JQ1 (1 μmol/L) or THZ1 (50 nmol/L) for the same time points. β-Actin serves as a loading control. TF, transcription factor.
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7171387713
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