Work

Adverse event data from the treatment arm of the CORTIS-01 trial

Year: 2026

Type: dataset

Abstract: Adverse event data from the treatment arm of the CORTIS-01 trial. 20,207 volunteers were screened at five geographically diverse sites across South Africa. RISK11 signature scores were measured by microfluidic RT-qPCR on mRNA derived from whole blood collected in PAXgene tubes. Participants were randomised into three groups and followed-up for 15 months to evaluate diagnostic and prognostic performance of RISK11 and to evaluate efficacy of high-dose isoniazid and rifapentine for prevention of incident TB. Data from the trial are available here: https://doi.org/10.25375/uct.13573337The current dataset includes adverse event data from the treatment group (375 participants), who received rifapentine and isozianid once-weekly, directly-observed, open-label isoniazid and rifapentine for 12 weeks.

Source: Open University of Cape Town (University of Cape Town)

DOI: 10.25375/uct.33071618

Authors: Thomas Scriba, Mark Hatherill, Humphrey Mulenga

Institution: University of Cape Town

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7171403120

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