Figure 4 from Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib
Year: 2026
Type: other
Abstract: Pathway analysis of SLFN11-associated genes in multiple myeloma (MM). A, GO enrichment analysis comparing MM samples with the highest and lowest SLFN11 expression (n = 844, divided by median expression). Red bars indicate pathways upregulated in SLFN11-high samples, whereas blue bars show pathways enriched in SLFN11-low samples. Left, biological processes; middle, molecular functions; right, cellular components. The x-axis represents −log10 (P value). B, GSEA comparing SLFN11-high vs. SLFN11-low samples. Top, MSigDB C5 ontology gene sets showing positive enrichment in SLFN11-high samples, including adaptive immune response (NES = 8.270) and immunoglobulin complex (NES = 8.004). Bottom, MSigDB hallmark gene sets showing negative enrichment in SLFN11-high samples, including MYC targets v1 (NES = −2.757) and G2M checkpoint (NES = −2.385). NES, normalized enrichment score.
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7171457421
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