Figure 7 from Schlafen 11 Is Overexpressed in Multiple Myeloma and Undergoes Nucleolar Translocation in Response to Bortezomib
Year: 2026
Type: other
Abstract: SLFN11 confers resistance to BTZ and sensitizes to TOP1 poisons. A, Time-course analysis of cell viability in WT and SLFN11 KO cells treated with BTZ. Left, KMS-34 cells treated with 2.5 or 5 nmol/L BTZ. Right, KMS-27 cells treated with 10 or 20 nmol/L BTZ. Cell viability was assessed by trypan blue exclusion at 0, 24, 48, 72, and 96 hours. B–D, Dose–response curves of WT and SLFN11 KO cells treated for 72 hours with BTZ (0–15 nmol/L; B), CPT (0–500 nmol/L; C) or exatecan (0–15 nmol/L for KMS-34, 0–50 nmol/L for KMS-27; D). Cell viability was measured using ATP assay. All experiments were performed in triplicate. Data are mean ± SD. *, P < 0.05; **, <0.01; ***, <0.001; ****, <0.0001.
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7171463776
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