[Distribution of serum HBV RNA in the natural history of chronic HBV infection and factors influencing HBV RNA negativity: a retrospective study stratified by HBeAg status].
Year: 2026
Type: article
Study design: Observational Study
Abstract: Serum HBV RNA levels in patients with chronic HBV infection are closely associated with HBeAg status, and HBeAg was an important factor influencing HBV RNA levels. HBV RNA negativity is independently associated with HBeAg negativity, lower HBsAg levels, and lower ALT levels. In the HBeAg-negative population, conventional clinical indicators have only modest discriminative ability for identifying HBV RNA negativity. HBV RNA may serve as a complementary biomarker to assess residual viral transcriptional activity.
Source: PubMed Central
Language: Chinese
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7171473050