Work

Light Chain Crystalline Proximal Tubulopathy and Podocytopathy With Staining for Both Light and Heavy Chain Immunoglobulin

Year: 2026

Type: article

Abstract: A 69-year-old male patient presented with weight loss and proteinuria. His medical history included papillary thyroid carcinoma. Laboratory findings showed proteinuria and high κ light chain levels in both urine and serum. Bone marrow aspiration revealed plasma cell myeloma of the IgA-κ type. Kidney biopsy revealed crystal inclusions in multiple locations, including podocytes and proximal tubular epithelial cells. Immunofluorescence and immunohistochemistry revealed positive staining for κ light chain and IgA. The patient was diagnosed with light chain crystalline podocytopathy and proximal tubulopathy. Our case presented some peculiarities: positive staining for heavy-chain IgA in addition to κ light chain and the absence of concurrent Fanconi syndrome or focal segmental glomerulosclerosis.

Source: Nephrology

DOI: 10.1111/nep.70251

Authors: Seoyoung Choi, Kyung Chul Moon

Institutions: Seoul National University, Seoul National University Hospital

Language: English

Topic: Multiple Myeloma Research and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,110