Dynamic Changes in Airway Microbiota and Immune Homeostasis in Patients With COPD and the Implications for Nursing Management
Year: 2026
Type: article
Study design: Observational Study
Abstract: Objective: The objectives of this study were to investigate changes in airway microbiota and immune markers across chronic obstructive pulmonary disease (COPD) stages and their associations with clinical phenotypes and nursing factors, providing a basis for precision nursing. Methods: A total of 284 stable COPD patients (Global initiative for chronic Obstructive Lung Disease [GOLD] grades 2–3) were enrolled. Sputum and clinical data were collected at baseline (T0), exacerbation (T1), and recovery (T2). Microbiota structure was analyzed via 16S ribosomal RNA sequencing, and levels of immune markers such as interleukin-8 (IL-8) and IL-1β were measured by enzyme-linked immunosorbent assay. Statistical analysis was performed by integrating clinical scale scores and nursing adherence data. Results: <0.05). Conclusion: The airway microbiota-immune axis in COPD patients demonstrates a disease stage-dependent imbalance, characterized by microbial dysbiosis and enhanced pro-inflammatory responses during acute exacerbation. Good nursing adherence can modulate this axis’s homeostasis, offering novel targets for precision nursing.
Authors: Yao Zhong, Meihua Wang, Qunqun Zhu
Institution: Hangzhou Xixi hospital
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7171497965