Work

Predominance of autoimmune heparin-induced thrombocytopenia in a nephrology department

Year: 2026

Type: article

Abstract: Heparin-induced thrombocytopenia (HIT) is a rare immunologic side effect of unfractionated heparin and low-molecular-weight heparin, occurring in approximately 0.065% of hospitalizations and associated with a mortality rate of 10% to 15% within 30 days [1,2]. It typically presents within 5 to 14 days of heparin initiation and is associated with a paradoxical prothrombotic state through immunoglobulin G antibodies directed against complexes of platelet factor 4 (PF4) and heparin, which activate platelets [3].

Source: Research and Practice in Thrombosis and Haemostasis

DOI: 10.1016/j.rpth.2026.106880