Systemic Inflammation and Outcomes After Mitral Edge‐to‐Edge Repair: Insights From the OCEAN‐Mitral Registry
Year: 2026
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Systemic inflammation is increasingly recognized as an important contributor to cardiovascular outcomes. High-sensitivity CRP (C-reactive protein) is an established biomarker, but its prognostic value after mitral transcatheter edge-to-edge repair remains unclear. Clinical parameters such as body temperature may also reflect systemic inflammation; however, their prognostic role in this setting is uncertain. We sought to investigate the association between baseline inflammation makers and long-term outcomes in patients undergoing mitral transcatheter edge-to-edge repair. METHODS: We analyzed 3511 patients from the OCEAN (Optimized Catheter Valvular Intervention)-Mitral registry with available CRP, categorized by Centers for Disease Control and Prevention/American Heart Association cutoffs: <1.0 mg/L (n=1216), 1.0-3.0 mg/L (n=988), and >3.0 mg/L (n=1307). Body temperature was also assessed as an exploratory inflammatory marker. RESULTS: During a median follow-up of 13 (interquartile range, 10-26) months, 826 deaths and 911 composite event of cardiovascular death or hospitalization for heart failure were observed. In multivariable models, both CRP and body temperature were associated with higher risk of death (CRP: hazard ratio [HR], 1.98 [95% CI, 1.63-2.40]; and body temperature: HR, 1.49 [95% CI, 1.25-1.78]). Patients with both elevated CRP (>3.0 mg/L) and high temperature (≥37.0 °C) had the highest risk. Sequential Cox analyses showed an incremental value of CRP beyond clinical, laboratory, and echocardiographic variables. The prognostic effect was most pronounced in patients without preprocedural inotrope use. CONCLUSIONS: Elevated CRP is an independent and incremental predictor of death and heart failure outcomes after mitral transcatheter edge-to-edge repair, with its prognostic impact amplified by higher body temperature. These findings highlight the importance of incorporating systemic inflammation into risk stratification for structural heart interventions. REGISTRATION: URL: https://www.umin.ac.jp/ctr/; Unique identifier: UMIN-ID: UMIN000023653.
Authors: Kazunori Omote, Masanori Yamamoto, Atsushi Sugiura, Tetsuro Shimura, Shunsuke Kubo, Yuki Izumi, Mike Saji, Masahiko Asami, Yusuke Enta, Shinichi Shirai, Masaki Izumo, Shingo Mizuno, Yusuke Watanabe, Makoto Amaki, Kazuhisa Kodama, Hisao Otsuki, Toru Naganuma, Hiroki Bota, Yohei Ohno, Masahiro Yamawaki, Daisuke Hachinohe, Hiroshi Ueno, Gaku Nakazawa, Toshiaki Otsuka, Kentaro Hayashida, OCEAN‐Mitral Investigators
Institutions: Hokkaido Cardiovascular Hospital, Toyohashi Heart Center, Nagoya Heart Center, Gifu Heart Center, Kurashiki Central Hospital, Sakakibara Hospital, Toho University, Mitsui Memorial Hospital, Sendai Kousei Hospital, Kokura Memorial Hospital, St. Marianna University School of Medicine, Shonan Kamakura General Hospital, Teikyo University, National Cerebral and Cardiovascular Center, Saiseikai Kumamoto Hospital, Tokyo Women's Medical University, New Tokyo Hospital, Sapporo Higashi Tokushukai Hospital, Tokai University, Saiseikai Yokohama Eastern Hospital, Toyama University Hospital, University of Toyama, Kindai University, Nippon Medical School, Keio University
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,810
OpenAlex ID: W7171518152