Work

Subdermal Bifunctional Insulin Delivery Implant Utilizing a Smart Pba Hydrogel Body and a Self-sealing Silicone Refill Cap

Year: 2026

Type: preprint

Abstract: This document details the architectural specification and numerical validation for project SUB-RESP-DIABETES-2026, a long-term, non-electronic subdermal implant engineered for automated glycemic regulation in Type-1 Diabetes. The primary body is constructed from a biocompatible polymer integrated with a glucose-responsive Phenylboronic Acid (PBA) Hydrogel, paired with a self-sealing medical-grade silicone dome for percutaneous micro-needle refills. Features a 24-hour dynamic kinetic simulation, mass transfer equations, and bio-integration frameworks (Zwitterionic PCBMA + VEGF angiogenic matrix).

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.21645629

Author: Mohammed Rashad, Mohammed Hussein Mohamed

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7171534555

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