Year: 2026
Type: preprint
Abstract: Glaucoma is an irreversible blinding disease that affects millions of individuals worldwide. Elevated intraocular pressure (IOP), regulated by the trabecular meshwork (TM) in the anterior eye, is the only modifiable risk factor. Human TM cells can be cultured from donor eyes, providing a precious resource for studying factors that induce or prevent glaucoma. The goal of this study was to produce datasets that define the molecular profile of human non-glaucomatous TM cells. Using 18 human TM cell strains cultured from non-glaucomatous individuals deposited from seven laboratories in the USA and UK, this study used transcriptomic, proteomic, lipidomic, and metabolomic analyses to characterize the molecular content of TM cells. The data herein provides the most comprehensive multiomic analyses of human TM cells to date and will be a useful resource for researchers and clinicians in the TM and glaucoma fields.
Authors: Anh H. Pham, Isabella G. Moceri, Zachary Batz, Nivedita Singh, Avinash Soundararajan, Katelyn Kane, Tutut Nurjanah, Emine Bilir, Rong Du, Yiqin Du, Milton A. English, Jennifer A. Faralli, Samuel Herberg, Stephanie How, Ruminder Preet Kaur, Susanna Li, Suhani Patel, Padmanabhan P. Pattabiraman, Carl M. Sheridan, Anand Swaroop, Ying Ying Sun, Neeru A. Vallabh, Sanjoy K. Bhattacharya, Donna M. Peters, Kate E. Keller
Institutions: University of Miami, National Institutes of Health, National Eye Institute, Indiana University Indianapolis, Indiana University School of Medicine, Florida Atlantic University, University of Liverpool, University of South Florida, University of Wisconsin–Madison, SUNY Upstate Medical University, Oregon Health & Science University, University of Wisconsin System
Language: English
Subfield: Ophthalmology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, Glaucoma Research Foundation, Research to Prevent Blindness, BrightFocus Foundation, Oregon Health and Science University, State University of New York, American Glaucoma Society, National Institutes of Health, School of Medicine, Indiana University, State University of New York Upstate Medical University, National Eye Institute
Awards: G2100497953, G313703007, G6585113062, G7986395380, G800051844, G8131162765, G8170374371, The role of glaucomatous trabecular meshwork cues in driving Schlemm's canal cell mechano-pathobiology, G9000089756, G9000329819, G9000342939, Core Grant for Vision Research, Role of cellular memory in glaucoma., Genetic and epigenetic regulation of retinal development, aging and evolution, Mechanisms, modeling and therapies of retinal and macular neurodegeneration, TM/SC-interface-on-a-chip for mechanistic studies of outflow regulation., Ophthalmology Core Facility, Mechanisms of Trabecular Meshwork Regeneration by Stem Cells, Miami Center for Vision Research
OpenAlex ID: W7171650296