Reviewer #3 (Public review): A whole-animal phenotypic drug screen identifies suppressors of atherogenic lipoproteins
Year: 2026
Type: peer-review
Abstract: In this important study, the authors have performed a zebrafish drug screen to identify suppressors of atherogenic lipoproteins.They utilize a well-established LipoGlo assay to find molecules that modulate these lipoproteins, identifying 49 potential hits and they perform validation experiments, including studies linking enoxolone to its likely inhibitory effect on a specific transcription factor, HNF4alpha.Overall, the results are convincing and robust, and will open up new areas of exploration for those investigators interested in in vivo lipid biology.
Source: eLife
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,500
OpenAlex ID: W7171684208