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Antitumor Activity of Orally Available Cyclic Peptide LUNA18 through Direct Pan-RAS Inhibition across Diverse RAS Genetic Alterations

Year: 2026

Type: article

Source: Molecular Cancer Therapeutics

DOI: 10.1158/1535-7163.mct-26-0262

Authors: Hitoshi Sase, Saki Michisaka, Yukako Tachibana, Masami Hasegawa, Toshihiko Fujii, Kana Takei, Tomoko Kanei, Naoaki Murao, Ryuichi Komatsu, Kentaro Asanuma, Shino Kuramoto, Norihito Shibahara, Atsushi Ohta, Mikimasa Tanada, Takuya Shiraishi, Hitoshi Iikura, Takehisa Kitazawa, Hiroshi Tanaka

Institution: Chugai Pharmaceutical Co., Ltd. (Japan)

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7171837795

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