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Association between Circulating Interleukin-2 and Clinical Outcomes in Patients with Acute Decompensated Heart Failure

Year: 2026

Type: article

Abstract: -transformed IL-2 was independently associated with 1-year MACE (HR = 1.212, 95% CI: 1.080-1.359, P = 0.001). Addition of IL-2 to the established clinical risk model significantly improved NRI (0.245, 95% CI: 0.015-0.370, P = 0.032) and IDI (0.019, 95% CI: 0.002-0.043, P = 0.028) for 1-year MACE. Elevated circulating IL-2 levels were independently associated with adverse 1-year clinical outcomes in patients with ADHF and provided incremental prognostic information beyond conventional risk factors. IL-2 may have potential utility for risk stratification in ADHF.

Source: International Heart Journal

DOI: 10.1536/ihj.25-557