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Perimesencephalic Subarachnoid Hemorrhage Presenting with Headache and Ocular Hemorrhage in a Patient with Chemotherapy-induced Severe Thrombocytopenia

Year: 2026

Type: article

Abstract: A 26-year-old female with severe thrombocytopenia (platelet count <20,000/μL) following combination chemotherapy (cisplatin, paclitaxel, pembrolizumab, and bevacizumab) for cervical cancer presented with new-onset headache and ocular hemorrhage. Perimesencephalic subarachnoid hemorrhage (pmSAH) was identified, which was subsequently complicated by disproportionate cerebral vasospasm and transient oculomotor nerve palsy. This case demonstrates that pmSAH, which is generally considered a benign venous hemorrhage, can follow an unusual course in the setting of profound bleeding diathesis and chemotherapy-induced vascular injury.

Source: Journal of the Korean Neurological Association

DOI: 10.17340/jkna.2026.0020

Authors: Hyo Jeong Lee, Moon Ho Park, Jong Hun Kim

Institution: Korea University Ansan Hospital

Language: English

Topic: Intracranial Aneurysms: Treatment and Complications

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7171844593