Work

Association of Thromboelastography With Hematoma Expansion and Disability in Spontaneous Intracerebral Hemorrhage

Year: 2026

Type: article

Abstract: Background and Objectives: Hematoma expansion (HE), an increase in bleeding into the brain, is a modifiable cause of disability and death after intracerebral hemorrhage (ICH). Some specialized hemostatic biomarkers are associated with HE. Widely available hemostatic biomarkers could improve our understanding of HE and lead to targeted treatments. Methods: We conducted a multicenter, prospective, cohort study of patients with spontaneous ICH between 2019 and 2023 at 6 medical centers across the United States. Patients with an initial CT scan within 12 hours of symptom onset were enrolled. All patients had initial and follow-up CT scans for HE calculation and a blood draw that occurred before follow-up imaging. Patients who received desmopressin were excluded from analysis. Correlation between continuous numerical variables (i.e., HE and hemostatic biomarkers) was calculated with Spearman correlation. Correlations between the 3-month modified Rankin Scale (mRS) and biomarkers were calculated using Kendall correlation. Results: = 0.01) were associated with the 3-month mRS. Discussion: Hemostatic biomarkers from TEG, particularly those related to clot strength and fibrin generation, were associated with subsequent HE and the mRS at 3 months. These results suggest that hemostatic biomarkers have potential to predict HE and functional outcomes in a broad swath of patients with spontaneous ICH.

Source: Neurology Open Access

DOI: 10.1212/wn9.0000000000000100