Innate Salt Sensitivity Syndrome (NaCl) as a Multisystemic Trigger of Inflammation, Autoimmunity, and Neuro-Endocrine Disorders
Year: 2026
Type: article
Abstract: Title: Innate Salt Sensitivity Syndrome (NaCl) as a Multisystemic Trigger of Inflammation, Autoimmunity, and Neuro-Endocrine Disorders Authors: Mohammad Reza Loughaei, Asal Sajedi Abstract: This article presents a novel hypothesis regarding "innate salt sensitivity" that extends beyond the classical hypertensive framework. According to this hypothesis, sodium consumption in susceptible individuals can trigger or exacerbate autoimmune diseases (including lupus, rheumatoid arthritis, multiple sclerosis, and diabetes) through activation of the SGK1 pathway and increased inflammatory Th17 responses. The paper also examines salt's effects on the gut-brain axis, precocious puberty, reduced bone mineral density, anxiety, and cardiovascular damage caused by industrial salt impurities. Finally, an industrial salt elimination protocol combined with natural salt replacement and a well-planned plant-based diet is proposed as a low-risk, effective intervention. Keywords: Salt Sensitivity, Autoimmunity, SGK1, Th17, Inflammation, Gut-Brain Axis, Precocious Puberty, Plant-Based Diet
Authors: Sajedi, Asal, Leghae, Mohammadreza
Language: English
Topic: Sodium Intake and Health
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7171869703
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