Work

From bench to chip: microfluidic integration for scalable DNA origami manufacturing and actuation

Year: 2026

Type: article

Abstract: DNA origami is a nanofabrication technique where a long DNA scaffold is folded using locally complementary staple strands to create predesigned two- and three-dimensional structures with desired shapes, sizes, and surface functionalities. While many of these structures have been proposed for applications in biosensing, nanorobotics, and targeted therapeutic delivery, among others, translating this technology from the bench to clinical and industrial settings faces significant challenges, especially in reproducibility, process scalability, and control precision. Microfluidic platforms offer potential solutions to these limitations by providing accurate control, process automation, and easy integration of multiple workflow steps within lab-on-chip devices. This review examines the potential role of microfluidic technologies in DNA origami production, characterization and actuation, highlighting advantages and future directions.

Source: Nanotechnology

DOI: 10.1088/1361-6528/ae93be

Authors: Aditya Shah, Anshul Nayak, Guillermo Ramirez-Alvarado, Gongchen Sun, Divita Mathur, Sebastian Sensale

Institutions: Indiana University Indianapolis, Case Western Reserve University, The University of Texas at San Antonio

Language: English

Topic: Advanced biosensing and bioanalysis techniques

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $3,325

Funder: Case Alumni Association