Work

Design of redox-responsive fluorescent nanoceria via AIEgen-functionalized dextran for bioimaging

Year: 2026

Type: article

Abstract: In this study, we report the design and comprehensive physicochemical characterization of a redox-responsive nanoplatform based on cerium oxide nanoparticles (nanoceria) functionalized with thiolated dextran bearing aggregation-induced emission luminogens (AIEgens). The surface engineering strategy, involving covalent grafting via disulfide bonds, was meticulously validated using a multi-technique approach (FTIR, NMR, TGA, and TEM). We demonstrate that this functionalization successfully enhances the colloidal stability of nanoceria while preserving the fluorescence properties of the AIEgens. Furthermore, we evidence a redox-triggered detachment of the polymer shell in the presence of glutathione, mimicking intracellular conditions. This work provides a versatile and well-defined synthetic route to create stable, responsive, and fluorescent nanoceria, representing a significant step toward the development of advanced smart nanomaterials for biomedical applications.

Source: Results in Chemistry

DOI: 10.1016/j.rechem.2026.103691

Authors: Cléa Chesneau, Laurent Michely, Angélique Goffin, Eric Leroy, Sabrina Belbekhouche

Institutions: Centre National de la Recherche Scientifique, Institut de Chimie et des Matériaux Paris-Est, Université Paris-Est Créteil, Laboratoire Eau, Environnement et Systèmes Urbains

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $1,870

Funder: Agence Nationale de la Recherche