Work

Synthetic studies on leptolyngbyalides A–C: stereoselective synthesis of the C1–C15 fragment

Year: 2026

Type: article

Abstract: We describe herein a stereoselective synthesis of the C1–C15 fragment of leptolyngbyalides A–C. A stereochemically modular synthesis of the C4–C12 domain harboring the configurationally unassigned C5, C7, and C9 stereogenic centers was achieved by taking advantage of chiral auxiliary-assisted diastereoselective reactions. Subsequent transformations including an aldol coupling, a Narasaka–Prasad reduction, and a Suzuki–Miyaura coupling completed the synthesis of the C1–C15 fragment, corresponding to an open-chain form of the macrocyclic skeleton of leptolyngbyalides A–C.

Source: Chemistry Letters

DOI: 10.1093/chemle/upag153

Authors: Keisuke Murata, Haruhiko Fuwa

Institution: Chuo University

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $1,003

Funder: Japan Society for the Promotion of Science