Modulating macrophage efferocytosis: Drug delivery strategies for enhancement, mimicry, and inhibition
Year: 2026
Type: review
Abstract: Efferocytosis, the non-inflammatory clearance of apoptotic cells, is essential for tissue homeostasis and inflammation resolution. Efferocytosis has different effects in the context of different diseases, providing a compelling therapeutic target. Impaired efferocytosis is linked to the progression of cardiovascular, autoimmune, and neurological disorders, whereas in tumors, efferocytosis often facilitates immunosuppression and metastasis. This review comprehensively summarizes recent advances in drug delivery systems (DDSs) designed for the modulation of macrophage efferocytosis. We first introduce the mechanisms of efferocytosis and its pathophysiological roles across diseases. Next, we thoroughly review DDSs designed to enhance, mimic, or inhibit efferocytosis, with a particular focus on various targeting methods to achieve precise efferocytosis modulation. Finally, we discuss translational challenges and propose future perspectives for efferocytosis-targeting therapies. This work aims to provide a foundational reference for the rational design of efferocytosis-modulating delivery systems and to underscore their therapeutic potential in a range of diseases.
Source: Acta Pharmaceutica Sinica B
Authors: Zhihua Liu, Jiahui Wu, Jiayan Lyu, Zhou Zhou, Yuan Huang
Institution: Sichuan University
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,600
OpenAlex ID: W7172338767