Legends of Supplementary Videos from Microglia Display Heterogeneous Initial Responses to Disseminated Tumor Cells
Year: 2026
Type: other
Abstract: Supplementary Video 1: Phagocytosis of DTCs by microglia A video showing the phagocytic behavior of microglia. The numbers on the top left represent (hours: minutes). The microglia (green) surround the cancer cells (red), after which the cells undergo apoptosis. Scale = 50 µm. This video corresponds to Fig. 3g. Supplementary Video 2: Diversity of microglial responses to DTCs visualized in vivo The interaction between microglia (green) and CMT167mCh (red) was tracked over time in vivo. These diverse responses and outcomes were captured within the same field of view in a single model. The numbers indicate the days since the CMT167mCh cell injection. Scale = 100 µm. This video corresponds to Fig. 2h. Supplementary Video 3: ΔCd24 and ΔCd47 enhanced elimination of DTCs by microglia In vivo time-lapse imaging of the indicated cell lines. The numbers on the top left indicate the days since the injection of tumor cells. This video corresponds to Fig. 6k.
Authors: Takahiro Tsuji, Haruka Hirose, Daisuke Sugiyama, Mariko Shindo, Rahadian Yudo Hartantyo, Yutaro Saito, Tsuyako Tatematsu, Shouta Sugio, Makoto Sanbo, Masumi Hirabayashi, Yasuhiro Kojima, Jun Koseki, Kazutaka Hosoya, Hiroshi Yoshida, Tatsuya Ogimoto, Yuto Yasuda, Kentaro Hashimoto, Hitomi Ajimizu, Yuichi Sakamori, Hironori Yoshida, Noritaka Sano, Masahiro Tanji, Hiroaki Ito, Kazuhiro Terada, Masatsugu Hamaji, Toshi Menju, Hiroyuki Konishi, Katsuaki Sato, Shogo Kumagai, Cyrus M. Ghajar, Daisuke Kato, Hiroshi Date, Akihiko Yoshizawa, Yoshiki Arakawa, Hiroaki Ozasa, Andrew J. Moorhouse, Teppei Shimamura, Hiroyoshi Nishikawa, Toyohiro Hirai, Hiroaki Wake
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7172433731