Work

Elevated cholesterol in APOE4 astrocytes drives mitochondrial cristae collapse and ATP synthase dysfunction

Year: 2026

Type: preprint

Source: bioRxiv (Cold Spring Harbor Laboratory)

DOI: 10.64898/2026.08.04.742391

Authors: Seungtae Lee, Mikel Munoz-Oreja, Marina Villar-Fernandez, Leire Goicoechea-Barrenechea, Uxoa Fernandez-Pelayo, Diego Perez-Rodriguez, Matthew Gegg, Amaia Lopez de Arbina, Antonella Spinazzola, Ian James Holt

Institutions: Biogipuzkoa Health Research Institute, Biomedical Research Networking Center on Neurodegenerative Diseases, Ministerio de Economía y Competitividad, The Royal Free Hospital, UCL Queen Square Institute of Neurology, University College London, Ikerbasque, University of the Basque Country

Language: English

Topic: Mitochondrial Function and Pathology

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

OpenAlex ID: W7172494689

Cites: 44

Cited by:

Related to: 10