Year: 2026
Type: article
Abstract: 帕金森病(Parkinson’s Disease, PD)是常见的中老年神经系统退行性疾病，以黑质致密部多巴胺能神经元变性丢失、α-突触核蛋白异常聚集为核心病理特征，现有疗法难以阻断病程且易产生副作用，针刺作为安全的辅助治疗手段，在改善其运动及非运动症状方面潜力显著。本文系统梳理近年相关文献，从α-突触核蛋白聚集及其清除途径、线粒体功能障碍与氧化应激、神经炎症、抗细胞凋亡、基底节神经递质及脑肠轴6个方面，综述针刺治疗PD的潜在分子机制，结合随机对照试验及Meta分析归纳临床疗效，并整合各通路构建作用网络、剖析现有研究局限，为针刺治疗PD的机制探索与临床应用提供参考。Parkinson’s disease (PD) is a common neurodegenerative disorder of the central nervous system in middle-aged and older adults. Its core pathological features include the degeneration and loss of dopaminergic neurons in the substantia nigra pars compacta and the abnormal aggregation of α-synuclein. Current therapies are unable to halt disease progression and often lead to adverse effects. Acupuncture, as a safe adjunctive treatment, shows significant potential in improving both motor and non-motor symptoms of PD. This review systematically summarizes recent literature and discusses the potential molecular mechanisms of acupuncture in treating PD from six aspects: α-synuclein aggregation and its clearance pathways, mitochondrial dysfunction and oxidative stress, neuroinflammation, anti-apoptosis, basal ganglia neurotransmitter regulation, and the brain-gut axis. We also summarize clinical evidence from randomized controlled trials and meta-analyses, construct an interactive network of related pathways, and analyze the limitations of current studies. The aim is to provide a reference for further mechanistic studies and clinical applications of acupuncture in the management of PD.
Author: 诺 程
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7172532496