Work

Redox-responsive polymeric nanocarriers for targeted delivery of bruceantin to pancreatic cancer

Year: 2026

Type: article

Abstract: ). Biodistribution studies in an orthotopic pancreatic cancer murine model revealed substantial accumulation of LHRH-targeted nanoparticles primarily in tumors following systemic administration, with minimal hepatic deposition. Furthermore, BCT-loaded nanoplatforms reduced tumor growth by ∼72.4% relative to controls, with no detectable adverse effects. Collectively, this work highlights the potential of LHRH-functionalized nanoplatforms as a promising strategy for the targeted treatment of pancreatic cancer with BCT, offering enhanced therapeutic efficacy with minimal systemic toxicity and paving the way for future clinical translation of this natural product.

Source: Nanoscale

DOI: 10.1039/d6nr00636a

Authors: Yitayal Admassu Workie, Kongbrailatpam Shitaljit Sharma, Vladislav Grigoriev, Yoon Tae Goo, Prem Singh, Ana Paula Mesquita Souza, Karthickraja Duraisamy, Akshay Vyawahare, Constanze Raitmayr, Neera Yadav, Chao Wang, Olena R. Taratula, Oleh Taratula

Institutions: Oregon State University, Addis Ababa Science and Technology University

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of State, Oregon Health and Science University, National Institutes of Health, National Cancer Institute, National Institute of Child Health and Human Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Development of magnetic hyperthermia for the systemic treatment of endometriosis, Intravascular Delivery of Nanoclusters for Treatment of Deep-Seated Cancers with Magnetic Hyperthermia, Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia, Nanoparticle-mediated placental imaging and magnetic hyperthermia for management of ectopic pregnancy

OpenAlex ID: W7196948794

FWCI:

Cites: 52

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Related to: 10