Work

Regulatory T-cell–biased IL-2 mutein inhibits development of allergen-specific TH2 cells and allergic asthma

Year: 2026

Type: article

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/j.jaci.2026.07.017

Authors: Amandine Selle, Alexis Yero, James J. Moon, Daniel J. Campbell, Andrew D. Luster

Institutions: Harvard University, Massachusetts General Hospital, University of Washington, Benaroya Research Institute

Language: English

Topic: Asthma and respiratory diseases

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Allergy and Infectious Diseases

Awards: Lung-Resident Memory Th2 cells in Asthma - New Therapeutic Targets, Mechanisms of Il-2-mediated immune tolerance, Chemokines and Th2 Cell Trafficking in Asthma, Mechanisms of autoimmune disease risk in IL2/IL2RA-dependent immune tolerance, Harvard Clinical and Translational Science Center, Allergen-specific lung-resident Tregs in asthma: Targetable suppressors of resident memory Th2 cells

OpenAlex ID: W7196985562

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