Enhancer-associated GRO-seq coverage data in embryonic stem cells.
Year: 2026
Type: dataset
Abstract: This dataset contains nascent transcription profiles and enhancer-associated GRO-seq coverage values derived from mouse embryonic stem cells (mESCs) and human embryonic stem cells (hESCs). The provided files include strand-specific GRO-seq coverage data across various classes of enhancer regions, categorized by genomic context (intergenic vs. intragenic), p300 occupancy, and proximity to transcription start sites (TSS). Enhancer annotations are based on the integration of H3K27ac ChIP-seq, p300 ChIP-seq, and GRO-seq signal. Coverage values are presented as tab-delimited `.txt` files and include both positive and negative strand data. Summary matrices are provided as `.xlsx` files for easier visualization. These processed datasets were used to quantify transcriptional activity at enhancers and assess enhancer dynamics in pluripotent stem cells. All data were processed using standard pipelines, including HOMER, MACS3, and deepTools. - **File formats**: text (tab-delimited), Excel (.xlsx) - **Species**: *Mus musculus* (mm10), *Homo sapiens* (hg38) All original raw datasets were obtained from publicly available sources. GEO/SRA accession numbers are listed in the Supplementary Table of the associated manuscript.
Source: Figshare
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7197006862