Work

Targeting cancer-intrinsic protein neddylation bypasses the loss of JAK/STAT signaling and overcomes acquired resistance to immunotherapy

Year: 2026

Type: preprint

Source: Research Square

DOI: 10.21203/rs.3.rs-9107846/v1

Authors: Yumeng Mao, Marta Rubies Bedos, Yonglin Lu, Eirini Voutsinou, Irineos Papakyriacou, Liam Alford, Rebeca Parracho, Vaishnavi Iyer, Antoni Ribas

Institution: Uppsala University

Language: English

Topic: Cancer Immunotherapy and Biomarkers

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: AstraZeneca, Parker Institute for Cancer Immunotherapy, Royal Swedish Academy of Sciences, Stiftelsen för Strategisk Forskning, Cancerfonden, Karolinska Institutet, Knut och Alice Wallenbergs Stiftelse, Novo Nordisk, Vetenskapsrådet, Uppsala Universitet, Science for Life Laboratory, National Institutes of Health, Uppsala Multidisciplinary Center for Advanced Computational Science

Awards: G1301692327, G1561542369, G3570292824, Genome-wide discovery of cancer intrinsic immune resistance mechanisms in triple negative breast cancer, G5853038575, G8211987807, Next Generation Cancer Immunotherapies to Defeat Melanoma

OpenAlex ID: W7197033076

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