Tyramine and its AmTYR1 receptor modulate attention in honey bees (Apis mellifera)
Year: 2024
Type: dataset
Abstract: Latent inhibition is a form of nonassociative conditioning. Honey bees show latent inhibition toward an odor they have experienced without association with food reinforcement. Individual honey bees from the same colony differ in the degree to which they show latent inhibition, and these individual differences have a genetic basis. To investigate the mechanisms that underly individual differences in latent inhibition, we selected two honey bee lines for high and low latent inhibition, respectively. We crossed those lines and mapped a Quantitative Trait Locus for latent inhibition to a region of the genome that contains the tyramine receptor gene Amtyr1. We then show that disruption of Amtyr1 signaling either pharmacologically or through RNAi qualitatively changes the expression of latent inhibition but has little or slight effects on appetitive conditioning, and these results suggest that AmTYR1 modulates inhibitory processing in the CNS. Electrophysiological recordings from the brain during pharmacological blockade are consistent with a model that AmTYR1 indirectly regulates at inhibitory synapses in the CNS. Our results therefore identify a distinct Amtyr1-based modulatory pathway for this type of nonassociative learning, and we propose a model for how Amtyr1 acts as a gain control to modulate hebbian plasticity at defined synapses in the CNS. Finally, our neural model suggests a mechanism for the broad pleiotropy this gene has on several different behaviors.
Source: DRYAD
Authors: Lei, Hong, Smith, Brian, Gaudau, Juergen
Institutions: Arizona State University, University of Münster
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7197050328