Work

Regulation of innate immune cell differentiation by mitochondrial nicotinamide adenine dinucleotide (NAD+) levels

Year: 2023

Type: conference-paper

Abstract: Macrophages can be divided roughly into two types in vitro: M1 or proEinflammatory, that display a glycolytic metabolism, and M2 or reparative, that largely rely on oxidative phosphorylation. Nicotinamide adenine dinucleotide (NAD+) is an essential cofactor in redox metabolism and metabolic signaling. To characterize the effect of mitochondrial NAD+ levels in the polarization of macrophages, we studied both the silencing and overexpression of MCART1 (SLC25A51), the mitochondrial NAD+ transporter (1) , in THPE1 cells and mouse bone marrow derived macrophages (BMDM).

Source: RUIdeRA - Institutional University Repository (University of Castilla-La Mancha)

Authors: Oliva Herrero, Aurea, Alonso Gómez, Andrea, Traba Domínguez, Javier

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7201191759

FWCI:

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Related to: 10