Year: 2026
Type: article
Abstract: Multimodal management of giant prolactinoma with extensive amyloid spherule deposition: a case report with review of the literature' [1].The authors present a remarkable and highly informative case of giant prolactinoma with extensive amyloid spherule deposition, emphasizing dopamine agonist resistance, aggressive local behaviour, and the potential value of multimodal treatment.The detailed discussion of radiotherapy, temozolomide, and possible restoration of dopamine sensitivity provides an important clinical perspective on a rare and challenging entity [1].I would like to highlight another clinically relevant aspect of giant prolactinoma that may deserve greater attention, particularly in male patients: skeletal morbidity.In the present case, the patient had longstanding hypogonadal symptoms, documented hypogonadotropic hypogonadism, and later required testosterone replacement; however, bone health evaluation was not described [1].Given the established adverse effects of hyperprolactinemia and hypogonadism on bone metabolism, assessment of fracture history and bone mineral density may provide useful complementary clinical information in such patients [2].
Source: Endocrine Journal
Author: Taner Dandinoğlu
Institution: Bursa City Hospital
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W7201834445