Work

Abietane‐Type Diterpenoids From Salvia kiangsiensis : Isolation, Semisynthesis, and Cytotoxicity of Their Oxime Ester Derivatives

Year: 2026

Type: article

Abstract: Systematic phytochemical investigation of whole plant of Salvia kiangsiensis led to the isolation of three undescribed abietane diterpenoids (1-3) and 24 known analogues (4-27), while compounds 2 and 3 belong to the 20-norabietane skeleton. Four derivatives (24a-24d) were also obtained through structural optimization. Their structures were elucidated by a combination of spectroscopic data, chemical methods, and x-ray diffraction. Cytotoxicity screening indicated that 24c, an oxime ester derivative of 24, exerted the most potent activity against the non-small-cell lung cancer (NSCLC) cell line H1975, with higher potency than the positive control cisplatin. Mechanism study revealed that 24c could promote cell-cycle arrest in S phase and induce cell apoptosis.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.71589

Authors: Wei‐Ye Wu, Lei‐Ming Wu, Lu Gan, Shu‐Qi Wu, Wei Liu, Sheng Yin

Institutions: Sun Yat-sen University, Yili Normal University

Language: English

Topic: Bioactive Natural Diterpenoids Research

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Natural Science Foundation of China, Natural Science Foundation of Guangdong Province