Figure 2 from Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses
Year: 2026
Type: other
Abstract: Simulations of cell migration as a function of subtype based on CD44-mediated cellular adhesive clutches. A, Schematic of proneural (low CD44) and mesenchymal (medium CD44, i.e., optimal) subtypes. B, Wind-rose plots of simulated cell trajectories on different stiffnesses (κsub = 0.1, 1, 10 pN/nm). C, Simulated cell migration random motility coefficients show higher migration with increased (optimal) adhesion across a range of substrate stiffnesses. D, Cell summed traction force exhibits higher traction forces with increased (optimal) adhesion across all stiffnesses. E and F, Cell spread area and aspect ratio increase with increased adhesion on substrate stiffnesses of 0.1 and 1 pN/nm. Error bars represent the SEM. +, P < 0.05; *, P < 0.01; **, P < 0.001; ***, P < 0.0001; ****, P < 0.00001, Statistical significance was assessed using the Kruskal–Wallis rank test with Dunn–Sidak correction.
Authors: Ghaidan A. Shamsan, Chao J. Liu, Brooke C. Braman, Ruyi Li, Susan K. Rathe, Aaron L. Sarver, Nima Ghaderi, Mariah McMahon, Rebecca L. Klank, Barbara R. Tschida, S. Joseph McFarren, Pamela C. Rosato, David Masopust, Jann N. Sarkaria, H. Brent Clark, Steven Rosenfeld, David A. Largaespada, David J. Odde
Subfield: Cell Biology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W7202207889
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