Figure 8 from Glioblastoma Subtypes Exhibit Distinct Migration Mechanics and Immune Responses
Year: 2026
Type: other
Abstract: BDTS of 3D NRAS/mesenchymal and PDGF/proneural tumors. A, Schematic showing a diagram of the model. B, Simulator output at day 0 and day 16 for PDGF and NRAS simulations. In NRAS simulations, dead cancer cells are larger gray spheres and T cells are smaller black spheres, see Supplementary Video S4. C, Cancer cell count over time showing the difference in tumor growth in the presence of T cells with simulated PDGF/proneural tumors growing faster than NRAS/mesenchymal tumors. D, Kaplan–Meier plot for NRAS/mesenchymal and PDGF/proneural tumor-bearing mice in WT vs. immunodeficient (Rag1−/−) background. NRAS/mesenchymal tumors show significantly reduced survival in Rag1−/− mice compared with WT (log-rank Mantel–Cox test P = 0.012). PDGF/proneural survival is not affected. E, Summary of the main findings depicting the relationship between molecular subtypes, cellular adhesion, cell migration, and immune response.
Authors: Ghaidan A. Shamsan, Chao J. Liu, Brooke C. Braman, Ruyi Li, Susan K. Rathe, Aaron L. Sarver, Nima Ghaderi, Mariah McMahon, Rebecca L. Klank, Barbara R. Tschida, S. Joseph McFarren, Pamela C. Rosato, David Masopust, Jann N. Sarkaria, H. Brent Clark, Steven Rosenfeld, David A. Largaespada, David J. Odde
Subfield: Genetics
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7202212334
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