Switch to once-weekly, single-tablet islatravir–lenacapavir from daily standard of care for HIV-1 (ISLEND-2): a multicentre, randomised, open-label, active-controlled, phase 3 non-inferiority trial
Year: 2026
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Source: The Lancet
Authors: Amy E Colson, Princy N Kumar, Peter J Ruane, Ploenchan Chetchotisakd, Winai Ratanasuwan, Afaaf Liberty, Ronald G Nahass, Alejandro Arenas-Pinto, Frank A Post, David A Baker, Pedro Cahn, Eveline Hofmann, Dai Watanabe, Po-Liang Lu, Anna H E Roukens, Miłosz Parczewski, Hongyuan Wang, Ke Chen, Fadi Shihadeh, Melissa Shaughnessy, Hadas Dvory-Sobol, Devi SenGupta, Cyril Llamoso, Martin Rhee, Onyema Ogbuagu, Pedro Cahn, Horacio Beylis, Florencia Cahn, Carina Cesar, Viviana De Lazzari, Luisina Fernandez, María Figueroa, Valeria Fink, Micaela Franchini, María Victoria Iannantuono, Herman Ludvik, Carolina Perez, Diego Salusso, Luciana Spadaccini, Isabel Lidia Cassetti, Viviana Bologna, Jorge Da Bouza, Mariana Espina Peña, Maria Laura Samaniego, Leia Zelarayan, Marcelo Losso, Angeles Acevedo, Bruno Boninsegna, Mariana Kundro, Tomas Schverdfinger, Guillermo Viloria, David Baker, Alexia Berkal, Eimear Byrne, Heather Farlow, Charles Geale, Mark O'Reilly, Chloe Williamson, Andrew Carr, Bronte Jeffrey, Jonathan Montemayor, Roman Pillay, Robyn Richardson, Jamie Rogers, Winnie Tong, Beng Eu, Verena Doolabh, Varun Kommidi, Andrew Lang, Helen Lau, Rebecca Overbury, Sally Price, Sven Strecker, Mark O'Reilly, Jakob Baxter, Eimear Byrne, Kathryn King, Miriam O'Brien, Matthew Shields, Michael Wheeler, Ian Woolley, Nanw Gwenallt, Sushena Krishnaswamy, Jillian Lau, James McMahon, Jessica OBryan, Anna Pierce, Stephanie Szabo, Mihiri Weerasuria, Georg Behrens, Gerrit Ahrenstorf, Renata Beider, Christine Knuth, Celia Jonsson-Oldenbüttel, Amelina Burkic, Karin Morbach, Sebastian Noe, Farhad Schabaz, Carmen Wiese, Ekkehard Wolf, Stefan Scholten, Irene Beckmann, Thomas Frohn, Tobias Göke, Nils Grote, Julia-Alina Meier, Andreas Roder, Stephan Schneeweiss, Richard Sinzig, Roger Vogelmann, Petra Buvari, Nicolai Härtel, Manfred Hensel, Christoph Plöger, Melanie Zunzunegui Timpanaro, Hiroyuki Gatanaga, Kyoko Akiyama, Naokatsu Ando, Takahiro Aoki, Yurie Chujo, Mone Edasawa, Tomoko Fujikawa, Ikumi Genka, Eri Inoue, Tsukina Katayama, Akira Kawashima, Yoshimi Kikuchi, Ryo Kuwata, Emi Matsumoto, Daisuke Mizushima, Takato Nakamoto, Atsumi Saijo, Katsuji Teruya, Hitomi Tsukada, Haruka Uemura, Yasuaki Yanagawa, Hirohisa Yazaki, Hidetoshi Igari, Ayumi Kase, Miwa Tada, Toshibumi Taniguchi, Chiho Watanabe, Misuzu Yahaba, Hiroshi Yoshikawa, Ei Kinai, Kagehiro Amano, Masato Bingo, Yushi Chikasawa, Michiko Ebisawa, Eri Gonda, Takeshi Hagiwara, Yuko Harada, Akito Ichiki, Sayuri Iwami, Shun Kaneko, Erika Kobayashi, Chisato Kusumi, Ryui Miyashita, Takashi Muramatsu, Kahori Okada, Yuka Ozaki, Asako Takeda, Rino Uchiyama, Hiromi Yamada, Tomoko Yamaguchi, Mihoko Yotsumoto, Hideta Nakamura, Mizuho Furuno, Shuhei Ideguchi, Mari Nakasone, Erina Suzaki, Kozue Taba, Kumiko Uechi, Ikuko Yonaha, Michinori Shirano, Rinrin Ageishi, Tomohiro Asaoka, Risa Fukuoka, Haruko Hironaka, Ko Iida, Ryo Morita, Misako Murakami, Hidenori Nakagawa, Asako Niwa, Kaori Okada, Rika Yamano, Dai Watanabe, Rie Fukuoka, Kazuyuki Hirota, Keiji Konishi, Takuro Matsumura, Yuko Nabata, Yasuharu Nishida, Yuka Saito, Asuka Senga, Takuma Shirasaka, Tomoko Uehira, Takashi Ueji, Erika Uno, Yoshiyuki Yokomaku, Chisato Asanuma, Yuko Hamano, Mayumi Imahashi, Ayumi Kogure, Megumi Ono, Nobuaki Sasaki, Anna Roukens, Hetty Jolink, Jessica Vlot, Marc van der Valk, Lotte Keikes, Jeannine Nellen, Annelou van der Veen, Milosz Parczewski, Bogusz Aksak-Was, Aneta Dembowska, Malwina Karasinska-Cieslak, Magdalena Leszczyszyn-Pynka, Magdalena Witak-Jedra, Bartosz Szetela, Magdalena Ciszek, Aleksandra Szymczak, Aleksander Zinczuk, Richard Kaplan, Peter Chodacki, Francois Cilliers, Sheetal Kassim, Noluthando Khiya, Gakiema Malan, Keren Middelkoop, Catherine Orrell, Tobeka Pamla, Doerieyah Reynolds, Tsholofelo Charmaine Setsiba, Mary Sihlangu, Vanessa Simkins, Yashna Singh, Viwe Soko, Dorothie Van der Vendt, Monica Vogt, Afaaf Liberty, Haseena Cassim, Lindiwe Maseko, Sisinyana Ruth Mathiba, Hilda Ndiweni, Maria De Lagarde Sebastián, Laura Bermejo, Otilia Bisbal, Asuncion Hernando Jerez, Juan Martín, Juan Martin Torres, Adriana Pinto Martinez, Federico Pulido, David Rial Crestelo, Rafael Rubio, Mireia Santacreu Guerrero, Joan Patricia Echeverria Bermudez, Susana Benet, Anna Bonjoch Badia, Josep Ferrer, Marcos Marques Sorinas, Ana Martinez, Angel Rivero, Alba San Jose, Jose Ramon Santos Fernandez, Juan Gonzalez Garcia, Maria del Mar Arcos Rueda, Victor Arribas, Jose Ignacio Bernardino de la Serna, Carmen Busca Arenzana, Juan Miguel Castro, Alejandro De Gea Grela, Luz Martin Carbonero, Rafael Mican Rivera, Maria Luisa Montes Ramirez, Luis Ramos, Luis Fernando Lopez-Cortes, Nuria Espinosa Aguilera, Marta Herrero, Manuel Francisco Liroa Romero, Silvia Llaves Flores, Francisco Javier Ortiz Ortega, Inmaculada Rivas, Cristina Roca Oporto, César Sotomayor de la Piedra, Alexandra Calmy, Yvan Gosmain, Olivier Nawej, Matthias Cavassini, Emeline Gauthiez, Dominique Niksch, Emma Schuller, Véronique Suttels, Chama Switalski, Florian Tagini, Eveline Hofmann, Lukas Baumann, Eugenie Colin-Benoit, Andrea Frei, Josina Gürtler, Manuela Herren, Daniela Hirter, Selina Krautter, Eloise Magnenat, Ursula Magyar, Benjamin Messerli, Gaétan Naudi, Andri Rauch, Pia Scherler, Cornelia Staehelin, Bernard Surial, Pascale Szalai, Theresa Von Sturm, Gilles Wandeler, Shu-Hsing Cheng, Cheng-Pin Chen, Wei-Lin Chen, Chien-Yu Cheng, Ya-han Fan, Shu-Yuan Li, Wen-Chao Weng, Chien-Ching Hung, Wen-Yu Chen, Wen-Chun Liu, Li-Hsin Su, Yi-Ching Su, Hsin-Yun Sun, Po-Liang Lu, Ya-Ting Chang, Tun-Chieh Chen, Yen-Hsu Chen, Yan-Zhen Hsu, Chung-Hao Huang, Chun-Yuan Lee, Chun-Yu Lin, Li-Ting Lin, Shang-Yi Lin, Chi-Jung Lu, Hung-Chin Tsai, Hong-Hong Chen, Jui-Kuang Chen, Chih-Chen Chou, Pei-Yun Chou, Pei-Hua Hsieh, Chen Jui-Kuang, Shin-Jung Lee, Yen-Ling Lu, Yu-Ting Tseng, Ya-Wei Weng, Kuan-Sheng Wu, Siou-Rong Wu, Chia-Jui Yang, Yu-Ping Cheng, Ying-Hsuan Chiang, Shih Chung-Yu, Jui-Chi Hung, Hui-Wen Lin, Mao-Song Tsai, Liu Yi-Ting, Anchalee Avihingsanon, Porntep Amornritvanich, Thura Kyaw Hein Minn Kyaw, Napon Hiranburana, Akarin Hiransuthikul, Yanisa Jarusyingdumrong, Hay Mar Su Lwin, Siwat Thammapiwan, Chuleeporn Wongvoranet, Khobchok Woratanarat, Ploenchan Chetchotisakd, Duangruethai Kamlek, Parichart Seawsirikul, Anchalee Tiyabut, Weerawat Manosuthi, Krittaecho Siripassorn, Lantharita Charoenpong, Supeda Thongyen, Phanasa Wongsasiripat, Nittaya Phanuphak, Jakkrapatara Boonruang, Maneepunnarai Jiwjinda, Piengfah Kamolrath, Pornpit Khomshuk, Siriporn Nonenoy, Siriporn Sittiho, Sirin Tangcharoensathien, Nipat Teeratakulpisarn, Supanat Thitipatarakorn, Sudarat Thongsuksangcharoen, Winai Ratanasuwan, Khuanchai Supparatpinyo, Nuntisa Chotirosniramit, Natthapol Kosashunhanan, Amaraporn Rerkasem, Patcharaphan Sugandhavesa, Taweewat Supindham, Daralak Tavornprasit, Alejandro Arenas-Pinto, Maeve Barlow, Laura Hennelly, Philip Oddie, Flora Olcott, Amanda Clarke, Lisa Barbour, Marion Campbell, Fiona Cresswell, Alyson Knott, Stephanie Mulhern, Kiersten Simmons, Julie Fox, Kathy Arbis, Piyumika Godakandaarachchi, Louise Terry, Margaret Johnson, Thomas Fernandez, Ana Luiza Pires Da Cunha, Pedro Simoes, Katie Spears, Thomas Swaine, Abigail Tobin, Chloe Orkin, Arnold Abraham, James Hand, Kyle Ring, Jozef Shaw, Lavanya Umashankar, Frank Post, Hannah Cameron, Lucy Campbell, Ronald Francisco, Nivenjit Kaur, Raye Marinas, Leigh McQueen, Nicholas Parkes, Fizza Qureshi, Kamvumbi Terrence, Helmut Albrecht, Divya Ahuja, Caroline Derrick, Nancy Haase, Laketa Hillman-Daughety, Monica Lynn, Alexander Milgrom, Kamla Sanasi-Bhola, Ogechika Alozie, Sonia Arzabala-Santillan, Cinthia Calleros Flores, Zoe Castro, Vanessa Gamboa, Grecia Heredia, Christopher Lopez, Gustavo Marquez, Alec Pinon, Andrea Rodriquez, Andrea Salcedo, Wenoah Veikley, Jessica Altamirano, Remy Bougeois, Madison Fink, Jose Ortega, Alma Toussaint, Emilio Vega, Archana Asundi, Daniel Chen, Dena Kivett, Samantha Roche, Sergio Romero, Manish Sagar, Paul Benson, Mark Bornstein, Amber Hooper, Mark Rosen, Mezgebe Berhe, Asia Ataghauman, Sarah Balogun, Christopher Bettacchi, Jessica Caldwell, Clinton Haley, Bryan King, Michelle Nwoha, Jessica Osunde, Daphney Robinson, Uriel Sandkovsky, Indira Brar, Khaled Almawri, Dalton Bender, Elena Groulx, Smitha Gudipati, Brianna Hohmann, Margaret Justusson, Erika Pastor, Shannon Payne, Zina Pinderi, Jeremiah Rooker, Nicholas Yared, Cynthia Brinson, Pete Camacho Jr., Steven Grantham, Christa Honsowetz, Alissa Milam, Steven Paris, David Wright, Thomas Campbell, Joslyn Axinn, Jennifer Bitzan, Kristine Erlandson, Sarah Mann, Jacqueline Rausch, Vanessa Sutton, Jennifer Chang, William Towner, Maricela Esqueda, Christina Flores, Vikas Jayadeva, Pham LePhong, Ya-Chien Lu, Jessie Masiclat, Reynalda Meza, Chinyere Ogugu, Domonique Osborn, Paula Pearlman, Gladiz Ponce, Amy Porter, Deborah Ramirez, Jesus Salina, Alesya P Sumantri, Jada Williams, Mona Zia, Lakshmi Chauhan, Cynthia Firnhaber, Hannah Kostoff, Alexandra Lee, Sarah Mann, Daniel Taylor, Billie Thomas, Amy Colson, Karen McLaughlin, Paul Cook, Jennifer Emberger, Lindsey Smith, Alexandra Stang, Catherine Creticos, Andrew Crone, Tina Ayilola, Danai Bemplidaki, Kathya Chartre, John Duly, William Kvasnicka, Zachary Long, Dan Rowell, Gordon Crofoot, Juston Baze, John Chapman, Kendrick Clack, Daniel Dyer, Maya Halliburton, Tatianna Mai, Derek Smith, Frederick Cruickshank, Thomas Dawson-Tripodis, Tuyana Matthews, Ashley Scott, Douglas Cunningham, Dena Banker, Sue Turner, Vincent DeGennaro, Zachary Henry, Daniel Brown, Chiavani Carland, Benjie Coopersmith, Polane Pierre, Emily Ruiz, Sheetal Sharma, Jalaya Williams, Alexandra Dretler, Milton Boden, Robin Dretler, Bhavani Kondamuri, Katherine Maclure, Jael Matos, Annapoorani Subramani, Anson Wurapa, Carl Fichtenbaum, Jenifer Baer, Makayla Bishop, Laura Cho, Jennifer Forrester, Linda Hinds, Shaina Horner, Moises Huaman Joo, Jaime Robertson, Michelle Saemann, Alan Smulian, Sarah Trentman, Joel Gallant, Linda Gorgos, Sonia Arzabala-Santillan, Erika Benson, Zoe Castro, Vanessa Gamboa, Sarah Hobongwana, Wendy Johnson, Christopher Lopez, Gustavo Marquez, Andrea Rodriguez, Tess Salazar, Wenoah Veikley, Cyril Gaultier, Ashraf Zadshir, Joseph Dahman, Lizeth Gutierrez, Leah Lane, Angel Marin, Golkoo Morcos, Agustin Peraza, Imelda Rojas, Patric Schine, Kim Skeete, Robert Grossberg, Uriel Felsen, Marcela Arizabaleta Ibanez, Margaret McCort, Eric Meyerowitz, Elvis Nelson, Beendu Pujar, Alfredo Silvestre, Julian Torres, Barry Zingman, Samir Gupta, Rory Duplantier, Karem Gonzalez Gomez, Danielle Grounds, Tina Nitsos, TaCarrea Shaw, Debbie Hagins, Mayah Bailey, Andrea Moon, Bonzo Reddick, Sonya Heath, Kennedie Bass, Paul Goepfert, Olivia Hogue, Heather Logan, Allison Self, LaTasha Vereen, Jennifer Hoffman, Jeffrey Stephens, Jeremy Aguinaldo, Michelle Damron, Jaime Fleming, Marnie Hill, Harold Katner, Michael Stevens, Andrew Jameson, William Boshoven, Melissa Brown-Culbertson, Katherine Schwass, Charles Tomlin, Lucas Vermaire, Susana Keeshin, Sally Bowen, Zoe Castro, Malia Iranon, Kristian Rivera, Andrea Rodriguez, Wenoah Veikley, Princy Kumar, Gayle Balba, Ronald Beaulieu, Matthew Copeland, Katherine Fan, Jai Kumar, Rebecca Kumar, Danial Mahmood, Bernardine Mohanraj, Joseph Timpone, Jennifer Manne-Goehler, Jennifer Johnson, Hannah Jordan, Cheryl Keenan, Daniel Kuritzkes, Paul Sax, Elizabeth Zhang, Cynthia Mayer, Lillie Bruton, Chrissy La Pointe, Sean Lefort, Karen Maroney, Tori Noris, Jean Thibault, Peggy Wallace, Cheryl McDonald, Ligta Cooper, Suzanna Farmer, Mark Hubert, Vivek Ramarathnam, Lakshmi Sambathkumar, Bryan Youree, Joseph McGowan, Jessica Charlton, Andrew Diaz, Gerald Field, Marina Guzman, Bruce Hirsch, Steven Hong, Jessica Rao, Frances Wallach, Mehri McKellar, Gary Cox, Laura Farrow, Justin Frye, Jacqueline Hodges, Shuqin Li, Rebecca Mangus, Nwora Okeke, Tina Watkins, Ronald Nahass, Enam Akasreku, Oluwole Atoe asokej, Sabitha Dasoju, Olga Kaplun, Rida Khan, Sharon Kohler, Eric Liu, Kathleen Seneca, Onyema Ogbuagu, Amit Achhra, Terese Critch-Gilfillan, Olayemi Osiyemi, Christina Campbell, Natasha Colman, William Habegger, Amber Herring, Jose Menajovsky-Chaves, Amanda Stroemberg, Moti Ramgopal, Brenda Jacobs, Ian Leeflang, Carly Sharp, Charlotte-Paige Rolle, Edwin DeJesus, Angela E'akels, Andrew Fontaine, Jeffrey Garrett, Federico Hinestrosa, Phillip Maxwell, Stephanie Skipper, Peter Ruane, Alejandra Galvan, Grecia Maldonado, Matthew Musikanth, Kenny Trinidad, Crystal Vargas, Peter Wolfe, Rachel Safran, Hayley Gower, Jessica Horton, McKenna Kobalter, Veronica Navarro, Lizette Santiago Colon, Carlos Del Valle, Tanya Schreibman, Brittney Dickerson, Stacy McNeill, Prerak Shukla, Lavinia Suciu, Jennifer Turfano, Anita Scribner, Gloria Ambrose, Christopher Burns, Shelby Marvin, Jihad Slim, Helen Fadoju-Oloyede, James Fallon, Amit Gupa, D'Ajanai Lee, Nicole McCormick, Gabe Montgomery, Jananthan Paramsothy, Cindy Saroop, Maria Elaine Szabela, David Stein, Olga Diaz, Julie Hoffman, Elizabeth Jenny-Avital, Jason Leider, Sindy Mora, Fanny Ita Nagy, Francisco Reinoso, Kelli Roe, David Wheeler, Yoseph Aldras, Amma Appiah-Asantewaa, Walid El-Nahal, Alexander Ogilvy, Donald Poretz, Alise Santos, Malika Welborn, Mitchell Whitehead, Zacarro Flucker, Brett Frans, Coby Myers, Hilary Rojas, Shelia Wilson, Lok Yung, Sorana Segal-Maurer, Gloria Brovchuk, Mari Tsovian, Glenn Turett, James Yoon, Carmen Zorrilla, Jessica Ibarra, Gloria Martino Gonzalez, Juana Rivera, Hiram Santiago
Institutions: Cambridge Health Alliance, Georgetown University, Georgetown University Medical Center, Ruane Medical, Khon Kaen University, Srinagarind Hospital, Faculty of Medicine, Khon Kaen University, Siriraj Hospital, Mahidol University, Chris Hani Baragwanath Hospital, Perinatal HIV Research Unit, University College London, National Health Service, King's College Hospital NHS Foundation Trust, King's College Hospital, Fundación Huésped, University of Bern, University Hospital of Bern, Osaka National Hospital, Kaohsiung Medical University, Kaohsiung Medical University Chung-Ho Memorial Hospital, Leiden University, Leiden University Medical Center, Pomeranian Medical University, Gilead Sciences (United States), Merck & Co., Inc., Rahway, NJ, USA (United States), Yale University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funder: Gilead Sciences
OpenAlex ID: W7202268679