Work

Orthogonal functionalization of lithium niobate nanoparticles with targeting aptamers and caged chemotherapeutics

Year: 2026

Type: article

Abstract: amide coupling to yield multifunctional constructs. The colloidal properties of the resulting NPs were assessed by dynamic light scattering (DLS), while drug and aptamer loadings were quantified by the fluorescence emission of the coumarinyl scaffold and Cy5-labelled aptamer, respectively. When SPAAC conjugation was implemented, higher aptamer and drug contents were observed, pointing toward the impact of surface chemistries on the availability of surface reactive handles for downstream functionalization. Overall, this work establishes peptide-coated LNO NPs as a versatile scaffold for the orthogonal anchoring of aptamer and caged therapeutic cargos, paving the way toward decoupled nonlinear optical imaging and light-triggered drug delivery.

Source: RSC Applied Interfaces

DOI: 10.1039/d6lf00132g

Authors: Alessandra Spada, Adrian Gheata, Ameni Dhouib, Yannick Mugnier, Sandrine Gerber-Lemaire

Institutions: École Polytechnique Fédérale de Lausanne, Université Savoie Mont Blanc

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

Open Access status: diamond

Funders: Agence Nationale de la Recherche, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Awards: G2992385397, DARE - DeepAndREsolved, G7554793706, Multimodal nanoprobes for high resolution and high penetration imaging