Work

Near Total Resolution of Severe Refractory Chronic Cough With Low‐Dose Sublingual Buprenorphine: Case Report

Year: 2026

Type: article

Abstract: Refractory or unexplained chronic cough (RUCC) is a cough lasting more than 8 weeks that persists despite guidelines-based evaluation and treatment, either because no cause is identified or because the cough continues after appropriate treatment of identified conditions. It can significantly impair functioning, sleep, and quality of life. Guideline-supported options remain limited. We report on a case of RUCC that was very effectively treated with low-dose sublingual buprenorphine. This partial μ-opioid agonist can offer greater safety and lower misuse liability compared to full opioid agonists or tramadol. Further study of this treatment option is warranted.

Source: Case Reports in Psychiatry

DOI: 10.1155/crps/1043995

Authors: David W. Streem, Jessica Benovic, Akhil Anand

Institution: Cleveland Clinic

Language: English

Topic: Respiratory and Cough-Related Research

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $790