Year: 2026
Type: article
Abstract: Ever since brain accumulation of gadolinium-based contrast agent (GBCA), especially in globus pallidus, was reported by Kanda et al. (1), the relationship between GBCA and neurodegeneration disease-in particular, Parkinson disease-has attracted significant academic attention in the field of radiology.Welk et al.'s 2016 (2) large population study showed no association between GBCA exposure and the incidence of parkinsonism.However, the effects of different types of GBCA on the risk of parkinsonism remain underexplored.Shin et al. (3) analyzed patients aged 40 years or older who underwent their first MRI examination between 2011 and 2014.Patients were stratified into a contrast-enhanced group-further subdivided into a linear GBCA group and a macrocyclic GBCA group-and a non-contrast group.Those undergoing brain or spine MRI were excluded to minimize selection bias from underlying neurological disease.The primary outcome was defined as all-cause parkinsonism to capture potential gadolinium-induced toxic parkinsonism.The incidence of all-cause parkinsonism, Parkinson's
Author: Won-Jin Moon
Institutions: Konkuk University, Konkuk University Medical Center
Language: English
Subfield: Materials Chemistry
Field: Materials Science
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W7202381845