Supplementary Figure S8 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: PSMAi-C’ dots modulate tumor and immune markers and upregulate interferon regulatory factors (IRFs) in the Hi-Myc model, with or without immune checkpoint blockade. (a, b) Gene expression profiles of tumor tissues harvested from animals 4 days after the final dose of a multi-dose (three doses every three days) regimen of i.v.-injected saline vehicle, ICB, PSMAi-C’ dots, or Dual Tx (n = 3 mice/cohort). Significant fold changes are indicated by values above 2, demarcated by dashed lines. (c-f) Representative tumor tissue specimens from all treatment arms were stained by (c) IHC and quantified for (d) cMyc, (e) Ki-67, and (f) PD-L1 (scale bar: 250 um). All numerical data are presented as mean ± s.e.m. 1-way ANOVA with Kruskal-Wallis test was performed in (a,b) and (d-f). *p < 0.05, **p < 0.01.
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203441630
Cites:
Cited by:
Related to: