Supplementary Figure S15 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: Particle-driven dual and triple therapies reshape immune cell heterogeneity and enhance macrophage–CD4+ T cell crosstalk, promoting CD8+ T cell infiltration in the Hi-Myc model. (a) Images depicting a representative tumor section in unmasked, masked and merged views. Masked view shows how tumor (pink) was delineated from stroma (cyan) and non-tumor regions (green and red). (b) Heterogeneous distributions of CD8+ T cells (red), F4/80+ macrophages (orange), CD4+ (green), CD4+-F4/80+ and merged (CD8+-CD4+-F4/80+) populations obtained from additional Hi-Myc model tumor sections following treatment with Dual Tx and Triple Tx; Scale bar: 100 um.
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203457997
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