Work

An EZH2–SREBP2 axis promotes cholesterol biosynthesis and represents a noncanonical vulnerability in tumorigenesis

Year: 2026

Type: article

Source: Nature Cell Biology

DOI: 10.1038/s41556-026-02048-x

Authors: Arum Kim, Bo Pan, Xufen Yu, Xing Gao, Nelli Khudaverdyan, Fatemeh Taherian, Chenxi Xu, Haiqing Zhong, Yan Xiong, H. Ümit Kaniskan, Masoud Vedadi, Jikui Song, Jian Jin, Ling Cai, Gang Greg Wang

Institutions: Duke University, Duke Medical Center, Fudan University, Icahn School of Medicine at Mount Sinai, University of California, Riverside, Ontario Institute for Cancer Research, University of Toronto, Duke Cancer Institute, University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center

Language: English

Topic: Cancer, Lipids, and Metabolism

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute

Awards: G2297578197, Discovery of First-in-class WDR5 PROTACs as a Novel Therapeutic Strategy for MLL-rearranged Leukemias, Targeting histone methyltransferase EZH2 for the treatment of hematological cancer

OpenAlex ID: W7203474282

FWCI: 2.628

Cites: 83

Cited by: 1

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