Supplementary Figure S7 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: Non-targeted C’ dots induce tumor-specific inflammatory responses in the Hi-Myc prostate cancer model. Ex vivo gene expression profiling of (a) tumor and (b) spleen harvested from Hi-Myc mice 4 days after the final dose of vehicle or non-targeted particles. Specific classes of genes (i.e., iron/ferroptosis-related, DAMPs, antigen presentation, and immune-related) were profiled. Transcripts were normalized to Gapdh and represented as fold changes, with significant changes indicated by values above 2 (dashed lines). Gene expression changes represented by bar plots at (c) 24 h and (d) 96 h post-particle administration in Hi-Myc mice, shown as log2 fold change transcript alterations relative to saline; significance indicated by values > 1 (solid lines).
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203475003
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