Supplementary Figure S4 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: Pharmacokinetic and biodistribution studies in Myc-CaP tumor-bearing mice following i.v.-injection of 89Zr-DFO-PSMAi-C’ dots. (a) PD-10 elution profile of 89Zr-DFO-PSMAi-C’ dots. Pure radiolabeled product elutes between 2.5-5 mL. (b) Stability of 89Zr-DFO-PSMAi-C’ dots in human (n = 3 samples) and mouse serum (n = 3 samples) relative to phosphate buffered saline (PBS, n = 3 samples). (c) In vivo targeted PET imaging of 89Zr-DFO-PSMAi-C’ dots in one of four representative Myc-CaP tumor-bearing mouse over a 72-hour period post-injection. (d) Tumor- and organ-specific time-activity curves and activity-to-background ratios were obtained from all mice (n = 4) in the study (c). (e) Biodistribution (represented as injected dose per gram tissue, %ID/g) of 89Zr-DFO-PSMAi-C’ dots in mice from (c) 72 hr post-injection of particle tracer. Data in (b) and (d – f) are presented as mean ± s.e.m.
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203476098
Cites:
Cited by:
Related to: