Supplementary Figure S5 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: Particle-mediated ferroptotic induction remodels the Myc-CaP TME to an anti-tumor proinflammatory phenotype (Day 7 post treatment). (a) Myc-CaP flank tumor-bearing mice were assigned to one of three treatment arms (n = 3/arm): saline vehicle, PSMAi-C’ dots, and PSMAi-C’ dots plus liproxstatin-1 (LP-1). Tumor growth was monitored for 7 days after the final treatment. (b) Representative H&E and c-myc staining of ex-vivo tumor sections from representative mice in (a); scale bar: 500 um. (c) Video highlighting differences in live untreated cells and dead (Sytox Green+) Myc-CaP cells using treatments in (a). IHC analyses of tumors harvested from (a) illustrating the percentage of (d) CD3+, (e) CD4+, (f) CD8+ T cells, (g) Iba1+ macrophages, and (h) c-myc + cells (n = 3–6 /arm). All numerical data are presented as mean ± s.e.m. 1-way ANOVA with Tukey's multiple comparisons test was performed for (d – h). *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.001.
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203478658
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