Supplementary Figure S3 from Reprogramming of TLR–Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer
Year: 2026
Type: supplementary-materials
Abstract: TRAMP-C2 cells exhibit concentration-dependent modulation of proinflammatory gene signatures following treatment with non-targeting C' dots. (a) Heatmap depicting different classes of genes (i.e., iron/ferroptosis-related, antioxidant, antigen presentation, DAMPS, and immune-related) and (b) correlative bars depict log fold transcript alterations in TRAMP-C2 cells exposed to increasing concentrations (0.1–15μM) of C’ dots for 72 h. Expression levels were normalized to GAPDH. All samples were run in triplicate.
Authors: Nabil A. Siddiqui, Li Zhang, Gabriel DeLeon, Nada Naguib, Tuo Zhang, Thomas P. Quinn, Feng Chen, Virginia Aragon Sanabria, Anusha Aditya, Daniel Penarete, Sebastien Monette, Fabio Socciarelli, Miles Pourbaghi, Rachel Lee, Chan Lee, Pat B. Zanzonico, Howard I. Scher, Michael Overholtzer, Ulrich Wiesner, Jedd D. Wolchok, Michelle S. Bradbury
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
OpenAlex ID: W7203490542
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