Mesoporous strontium silicates nanostructures as potential bone regeneration tool: an engineering approach to tune shape/structure- Data Sharing Archive [Dataset]
Year: 2026
Type: dataset
Abstract: Mesoporous silicates nanoparticles are known to find application in various fields ranging from medicine to devices. In addition, with the incorporation of metal within the silicate domain, the nanoparticles have advanced the tissue engineering field by tailoring the cellular function with for therapeutic response. However, the literature is limited by methods, not exploring the synthesis of these nanoparticles with different sizes and shapes. So, we optimized the reaction conditions using a Design of Expert (DoE) approach for the synthesis of mesoporous Strontium silicate nanostructures (NS) (nanoparticles – NPs and nanorods – NRs) with different physico-chemical properties. The conditions allowed change in shape from NPs to NRs by tailoring the concentration of liquid ammonia (NH4OH, 82.7mM to 248.2mM) during the pre-synthesis incubation state. In addition, the optimized reaction conditions allowed modulating the physico-chemical properties such as surface area, surface charge, amount of metal, pore diameter, pore volume, tailored degradation profile and release profile of loaded drug or model drug (gentamicin). Finally, the protocol has the advantage to allow incorporation of other metals such as cerium, rhodium, and ruthenium independently and or in combination. We can speculate using the protocol different metal with similar reaction profile to Sr, Ce, Rh, and Ru can be exploited to dope the mesoporous metal silicate nanostructures.
DOI: 10.13020/5f90-e843
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W7203539758